Intra-abdominal pressure at ICU admission: Evaluation as a predictor of severity and mortality in severe acute pancreatitis
Methods. A retrospective analysis of 50 patients with SAP admitted to the ICU of a tertiary-care Indian institute over a period of 3 years was done. Data relating to demographic profile, cause of pancreatitis, ICU admission, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, Sequential Organ Failure Assessment (SOFA) score, IAP, interventions instituted and mortality were analysed.
Results. Biliary stones (38%) were the most common cause of acute pancreatitis. Survivors differed from non-survivors with respect to organ failure, APACHE II and SOFA scores and IAP on admission. There was a significant correlation between IAP on ICU admission and admission SOFA (r=0.56, p<0.001) and APACHE II (r=0.54, p<0.001) in predicting mortality. Patients with elective admission had a mortality rate of 53% (20/38) compared with 83% (10/12) for those admitted as emergencies. Analysis of receiver operating characteristic curves for detecting mortality revealed an area under the curve of 0.915 (95% confidence interval (CI) 0.83 - 0.99) for IAP, 0.826 (CI 0.71 - 0.93) for SOFA, and 0.831(95% CI 0.71 - 0.94) for APACHE II.
Conclusion. IAP at ICU admission is a useful predictor of severity of illness and mortality in SAP.
Ratendar Kumar Singh, Department of Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India
Parnadi Bhaskar Rao, Department of Anaesthesiology and Critical Care, Pondicherry Institute of Medical Sciences (PIMS), Pondicherry, India
Arvind Kunar Baronia, Department of Critical Care Medicine, SGPGIMS, Lucknow, India
Banani Poddar, Department of Critical Care Medicine, SGPGIMS, Lucknow, India
Afzal Azim, Department of Critical Care Medicine, SGPGIMS, Lucknow, India
Mohan Gurjar, Department of Critical Care Medicine, SGPGIMS, Lucknow, India
Neha Singh, Department of Anaesthesiology and Critical Care, PIMS, Pondicherry, India
Vasudevan Senthilvel, Department of Community Medicine, PIMS, Pondicherry, India
Kamlesh Singh, Clinical Epidemiology, Chhatrapati Sahuji Maharaj Medical University, Lucknow, India
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Date published: 2012-07-09
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